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Triple mechanism of action for complete control of endometriosis symptoms

  • Relieves inflammation and pain
  • Stops the growth of endometriotic tissue
  • Reduces the possibility of recurrence of symptoms
Image of Lekolid™ box packaging
Photo of a happy woman in the sun

Ask your gynecologist today.

1 in 5-10 women in the reproductive period suffer from endometriosis.

30-50% of women with endometriosis suffer from infertility!

A completely natural product, a dietary supplement, with patented active technology, for the treatment of endometriosis

The components of LekolidTM-a act synergistically on the symptoms of the disease.

Image of turmeric powder (indian saffron)

Turmeric or Indian saffron, is one of the plants classified as GRAS – Generally Recognized As Safe Substances.

The active substances are curcumin and curcuminoids which act by blocking the growth and spread of endometriotic tissue. It also has anti-inflammatory and antioxidant effects, important in suppression of pain and other symptoms of endometriosis.

Quercetin belongs to the class of flavonoids, and like curcuminoids it acts by blocking the growth of endometriotic tissue, and acts anti-inflammatory and antioxidant. Quercetin in Lekolid™-u originates from the extract of Sophora japonica (Japanese pagoda tree).

Photo of quercetin
N-Acetyl Cysteine (NAC) visual

N-Acetyl Cysteine (NAC) is a form of L-cysteine ​​and is known for its antioxidant action. It leads to a significant reduction in the volume of endometriotic cysts.*

*Porpora M.G. et. al. A. Promise in the Treatment of Endometriosis: An Observational Cohort Study on Ovarian Endometrioma Reduction by N-Acetylcysteine. Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 240702

ENDOBASP® technology provides the tablet with efficient absorption and bioavailable substances that are not normally absorbed.

ENDO – endometriosis
B – bromelain
A – L-arginine
S – sucrester
P – piperine

ENDOBASP® technology is a patented innovative technology which, thanks to the synergy of absorption drivers (bromelain, l-arginine, sucrester, piperine) makes active ingredients in LEKOLIDTM-a highly bioavailable in the small intestine and improves anti-inflammatory and antiproliferative activity.

It also provides a gastroprotective effect of the tablet.

Endometriosis

Endometriosis is defined as the presence of endometrial-like tissue outside the uterus, leading to a chronic inflammatory tissue reaction, pain, and infertility. It is most often found on: ovaries, fallopian tubes, tissue that holds the uterus in place (ligaments), the outer surface of the uterus, but sometimes it can also be found on the vagina, cervix, bowel, bladder, rectum…

It is a relatively common diagnosis, but unrecognized.

Just as the endometrium inside the uterus has a menstrual cycle, so the endometrium outside the uterus goes through the same phases.

The endometrium outside the uterine cavity desquamates inside the organ on which it is located, causing irritation, inflammation and later adhesions. The adhesions enable bonding between the surrounding tissue to the uterus, thus reducing its function.

Endometriotic cysts on the ovary are known as chocolate cysts..

endometriosis.jpg
1Uterus
2Fallopian tube
3Ovary
4Ovarian ligament
5Endometric lesions
6Endometrium
7Vagina
  • 1 in 5-10 women in the reproductive period suffer from endometriosis.
  • 30-50% of women with endometriosis suffer from infertility!
Endometriosis, pain

Endometriosis is an inherited condition that is influenced by genetic and environmental factors:

1. Daughters and sisters of women with endometriosis have 6 times higher risk
2. Women of age 25-40 years
3. Women with low progesterone levels
4. Prolonged exposure to estrogen: i.e. late-onset menopause or early menarche
5. History of menstrual complications (i.e. long menstrual cycles, frequent periods)
6. If the woman did not give birth
7. High intake of red meat and fat
8. High alcohol intake
What are the symptoms of endometriosis?
  • Chronic pelvic pain
  • Painful menstruation (dysmenorrhea)
  • Heavy menstrual bleeding
  • Chronic physical exhaustion
  • Pain during sexual intercourse
  • Pain during ovulation
  • Pain during peristaltic bowel movements (movement of food in the intestines) or during urination
  • Back pain
  • Bloating…

WHO (World Health Organization)

When do we suspect endometriosis?

Suspected endometriosis (including young women of 17 years of age and younger) include presence of 1 of the following symptoms or signs:

  • Chronic pelvic pain
  • Pain associated with menstruation (dysmenorrhea) that affects daily activities and quality of life
  • Deep pain during or after sexual intercourse
  • Gastrointestinal symptoms are cyclical or associated with menstruation, especially pain during peristaltic bowel movements
  • Menstrual-related urinary symptoms, especially blood in the urine or pain during urination
  • Infertility associated with one or more of these symptoms

NICE (The National Institute for Health and Care Excellence) Therapy Guide 2017

Effect

LEKOLID™ technology has a triple effect by blocking the growth of endometrial tissue, relieving pain and inflammation, and relieving oxidative stress.
Endometriosis effect graphic

Triple mechanism of action for complete control of symptoms

Triple mechanism of action for complete control of symptoms

Clinically confirmed 

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30 gastro-resistant tablets

Dosage and use

One tablet daily with a teaspoon of olive oil or during a meal to improve the absorption of active ingredients

LEKOLID™ 1 TABLET
Quercetin 200 mg
Turmeric 210 mg
   curcuminoids 200 mg
N-acetylcysteine 150 mg

Recommended use: 1 tablet daily during a 3-month cycle.

The product is not intended for patients sensitive to any of the ingredients of the product, pregnant women, nursing mothers and children under 3 years of age, patients with bile duct obstruction and gallstones, as well as patients on anticoagulant therapy. If necessary, it can be combined with other drugs: contraceptives or hormones and pain medications.

It can also be used after surgery, in order to reduce the possibility of recurrence of symptoms. There are no known side effects, no interactions with other drugs and no restrictions on use. It does not contain gluten or lactose.

BEFORE LEKOLID

Anna

Anna

24 years, has not given birth, wants children

  • Early menarche
  • Regular, heavy and painful menstruation
  • Pain during intercourse and postcoital bleeding
  • Constipation and bloating
  • TVUS negative
  • Therapy: NSAIDs for pain and contraceptive therapy
Helen

Helen

32 years, has not given birth, wants children

  • Irregular cycle, heavy menstrual bleeding
  • Chronic mild pelvic pain
  • Positive family history of endometriosis (mother, sister)
  • TVUS showed smaller cyst on ovary
  • Blood screening: elevated estrogen, CA-125 normal
  • Therapy: hormone therapy (norethisterone orally 6 months)
Mary

Mary

39 years old, gave birth

  • Deeply infiltrated endometriotic changes
  • Disorders and threatening infertility
  • TVUS shows ovarian endometrioma
  • Blood screening: elevated estrogen, CA-125 slightly elevated
  • Therapy: laparoscopic surgery of endometrioma and adhesions
  • After laparoscopy GnRH therapy during 6 months
Lekolid™ logo

AFTER LEKOLID THERAPY

Photo of Anna, Helen and Mary together

Anna

3 months of therapy
1 tablet daily, 2 during the cycle

  • Feels pain much less often and the pain is much milder (54.5% reduction of dysmenorrhea, 51.7% dyspareunia, 63.1% pelvic pain)*
  • Rarely needs NSAIDs
  • Normalization of menstrual bleeding
  • Does not have to use contraceptive therapy because she wants a baby
  • Increased possibility of spontaneous pregnancy

Helen

Long-term therapy
1 tablet daily

  • Normalization of the menstrual cycle
  • Regression of ectopic foci, reduction of inflammation
  • The need for surgery is delayed
  • Increased possibility of spontaneous pregnancy
  • Long-term infertility therapy
  • No adverse effects (effects on bone density or platelets levels)

Mary

During GnRH therapy and long-term therapy, 1 tablet per day

  • Reduced possibility of recurrence of endometriosis (percentage of recurrence of endometriosis after conservative surgery is 21.5% after 2 years and 40-50% after 5 years. NICE)
  • Relieved pain and inflammation

Clinical evidence

Evaluation of the efficacy and safety of oral use of LekolidTM in women suffering from endometriosis

40 patients diagnosed with endriometriosis – 1 tablet daily of LEKOLIDTM, duration of therapy 2-3 months

DYSMENORRHEA

R = -54,5% / p < 0,01

DISPAREUNIA

R = -51,7% / p < 0,01

PELVIC PAIN

R = -63,1% / p < 0,01

USE OF NSAIL

R = -48,1% / p < 0,01

Estimation of pain using a numerical scale

LEKOLID™ is safe and effective in reducing inflammation and proliferation of ectopic endometrial tissue associated with painful symptoms of endometriosis. LEKOLID™ is recommended for:

  • patients who cannot use NSAIDs, steroids, androgens or antiestrogens due to complications,
  • patients who have undergone ablation surgery, such as laparoscopy or laparotomy
  • patients receiving pharmacological adjuvant therapy.

Mario Fadin, Mariaceleste Nicoletti. Evaluation of the effectiveness of Alliendo® in reducing hyper-proliferation and inflammation of ectopic endometrium in women suffering from endometriosis. In vitro and in vivo study reports. Pharmanutrition Functional Foods 2019

Woman in pain

Where to buy?

You can buy Lekolid™ in all better-stocked pharmacies.

Contact



    Exclusive distributor for Serbia,
    Bosnia and Herzegovina, North Macedonia and Croatia:

    Oktal Pharma logo

    Exclusive distributor
    for Montenegro:

    Farmont logo